Inadequate/Extensive Metabolizers, CYP2D6 The development in the Energetic metabolite, M1, is mediated by CYP2D6, a polymorphic enzyme. Somewhere around 7% of the inhabitants has minimized activity of the CYP2D6 isoenzyme of cytochrome P450 metabolizing enzyme system. These persons are “weak metabolizers” of debrisoquine, dextromethorphan and t
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